Acylation reagents for GC - Anhydrides

Acylation reagents for GC - Anhydrides
For improved volatility, better thermal stability or low limit of detection in gas chromatography prerequisite: quantitative, rapid and reproducible formation of only on derivative halogen atoms introduced by derivatisation (e.g. trifluoroacetates) allow specific detection (ECD) with the advantage of high sensitivity elution order and fragmentation patterns in MS can be influenced by a specific derivatisation.
Reagents for silylation - alkylation (methylation) - acylation are available.
Acylation with fluorinated acid anhydrides can be used for alcohols, phenols, carboxylic acids, amines, amino acids and steroids forming volatile, stable derivatives suited for FID as well as for ECD detection.

by-products of acylation with anhydrides: corresponding acids
excess reagent and the acid formed have to be removed

Heptafluorobutyric acid anhydride (HFBA)
m.w. 410.06, Bp 106 - 107°C (760mm Hg),
C3F7 - CO - O - CO - C3F7
density d20°/4° = 1.665

Tuotekoodi Valmistaja Nimi Description Capacity (ml)
4001479 701110.110
Macherey-Nagel GmbH & Co. KG
Acylation reagent HFBAChemical Kit 9 II 0.01 kg/L
1
HFBA 10
4001480 701110.201
Macherey-Nagel GmbH & Co. KG
Acylation reagent HFBA
20
HFBA 1
4001481 701110.510
Macherey-Nagel GmbH & Co. KG
Acylation reagent HFBAUN 3316 Chemical Kit 9 II
5
HFBA 10

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