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SEMINAR at 10:00-11:00, Registration link Matribot bioprinter LIVE DEMOS at 11:00-12:30

Registration is only for the Corning seminar. You are also most welcome to our nonstop demos and exhibition between 11:00-12:30am.

3D Cell Culture Technologies as Disease Models

In recent years, three-dimensional (3D) cell culture models have been emerging as the preferred in vitro cancer model as they better mimic the in vivo tumor microenvironment. For instance, 3D cultures develop hypoxic cores and demonstrate gradients of soluble factors and a diffusion profile for drugs similar to solid tumors. There have been also several recently established disease models involving human induced pluripotent stem cell (hiPSC)-derived 3D organoid culture systems. These systems also enable the use of patient-derived cells to generate models that provide valuable insight into the mechanism and progression of many diseases. Understanding the interactions between cancer cells and other cell types in the tumor microenvironment is also critical to predicting therapeutic efficacy.

This seminar will discuss the following topics:
• Short introduction to 3D cell culture.
• Benefits of 3D versus traditional cell culture technologies as disease models.
• Assay techniques in spheroid microplates.
• Example of 3D cancer models and technology tools used to better capture the complexity of the tumor microenvironment in assay-compatible formats.
• Use of hiPSC-derived 3D organoid and/or permeable support culture systems to create disease-specific tissue/organ models e.g. brain, liver, pancreas, intestinal, lung, skin, retina.

Applications discussed:
* Neurosphere stem cell model
* Generating intestinal organoids for HTS
* 3D glioma blood brain barrier model for HTS
* A Novel Spheroid-based Three-dimensional Invasion Model

 

Speaker's biography:
Dr. Raquel Matos
Scientific Support Manager EMEA
Corning Life Sciences

Raquel received her Ph. D degree in Natural Sciences from the Heidelberg University, Germany in 2009 after studying protein biochemistry and gene repression during development at the EMBL, Heidelberg, Germany. Afterwards, she has worked on gene expression differences between healthy mammalian cells and melanoma cells at IREBS, Strasbourg, France and as a technical support specialist for Merck KGaA (Millipore) with a focus on the protein detection portfolio. Raquel has joined Corning Life Sciences in 2017 as the Scientific Support Manager, establishing the new team in Amsterdam, The Netherlands.

 

Matribot bioprinter LIVE DEMOS at 11:00-12:30

With Matribot the dispencing and printing of Matrigel matrix and other ECM hydrogels are easy, watch the video!

 

 

 

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